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Homocysteinaemia is a condition characterized by disruption of homocysteine metabolism in the body which has been established as a risk factor for development of cardiovascular disorders. Homocysteinaemia is thus considered as one of the parameters that are affected by physical exercises (by vitamin B12) being implicated in the effects experienced by the immune system (Auer, et al.). According to Dr. MaCnulty, evidence from epidemiological studies and clinical studies indicate that more than 10, 000 people have an elevated level of plasma and this is hyperhomocysteinaemia disease.
What is Thrombotic Disease?
Thrombosis is the formation of a blood clot that blocks a blood vessel. There is a relationship between hyperhomocysteinemia and the arterial disease. There is evidence of an observed precocious arterial thrombosis in homocystinuric patients.
What are Thrombotic Symptoms?
Although the number and type of symptoms vary depending on the individual, typical thrombotic symtoms include pain in the legs, feeling heavy, tired, swelling, cramping and an itchy feeling. These symptoms will tend to worsen when standing. Clinical signs include swelling and a bluish discoloration of the leg or toes (Post-Thrombotic Syndrome).
Treatment for Thrombotic Disease
Experiments have shown that controlled defibrination can offer some treatment promises for thrombotic disease (Bell, et al 1968). However, recent research shows that purpura fulminans of about 10-20 mL/kg of ffresh plasma containing protein concentrations can be used to treat this condition especially in infants. Long-tern treatment will include offering an oal anticoagulant therapy, liver transplantation or replacing protein C (Andrew, et al).
Treatment for Homocysteinaemia
Treatment for Homocysteinaemia varies depending on the cause of the problem. However, it is generally agreed that vitamin supplementation of B6 and B12 are effective in reducing concentrations of homocysteine. Some patients also respond well to small doses of folate (less than 5mg daily) which decreases homocysteine concentrations (Auer, et al).
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